Multiple Sclerosis / Neuroinflammation

My research activity in DTI development to assess both inflammatory and neurodegenerative components in Multiple Sclerosis (MS) and other neuro-inflammatory diseases (selected original publications in peer-reviewed journals):

  1. Kugler, V.A., Deppe, M., 2018. Non-lesional cerebellar damage in patients with clinically isolated syndrome: DTI measures predict early conversion into clinically definite multiple sclerosis. Neuroimage Clin.Volume 19, 633-639.
  2. Miske, R., Gross, C.C., Scharf, M., Golombeck, K.S., Hartwig, M., Bhatia, U., Schulte-Mecklenbeck, A., Bonte, K., Strippel, C., Schols, L., Synofzik, M., Lohmann, H., Dettmann, I.M., Deppe, M., Mindorf, S., Warnecke, T., Denno, Y., Teegen, B., Probst, C., Brakopp, S., Wandinger, K.P., Wiendl, H., Stocker, W., Meuth, S.G., Komorowski, L., Melzer, N., 2017. Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration. Neurol.Neuroimmunol.Neuroinflamm. 4, e307.
  3. Deppe, M., Tabelow, K., Kramer, J., Tenberge, J.G., Schiffler, P., Bittner, S., Schwindt, W., Zipp, F., Wiendl, H., Meuth, S.G., 2016. Evidence for early, non-lesional cerebellar damage in patients with multiple sclerosis: DTI measures correlate with disability, atrophy, and disease duration. Mult.Scler. 22, 73-84.
  4. Deppe, M., Kramer, J., Tenberge, J.G., Marinell, J., Schwindt, W., Deppe, K., Groppa, S., Wiendl, H., Meuth, S.G., 2016. Early silent microstructural degeneration and atrophy of the thalamocortical network in multiple sclerosis. Hum.Brain Mapp. 37, 1866-1879.
  5. Deppe, M., 2015. Ist die Hirnatrophie ein sinnvoller Parameter? Kontra: Keine Entscheidungsrelevanz ohne Standards, verfügbare Verfahren und Validierung. DNP – Der Neurologe & Psychiater 16, 18-19.
  6. Droby, A., Lukas, C., Schanzer, A., Spiwoks-Becker, I., Giorgio, A., Gold, R., De, S.N., Kugel, H., Deppe, M., Wiendl, H., Meuth, S.G., Acker, T., Zipp, F., Deichmann, R., 2015. A human post-mortem brain model for the standardization of multi-centre MRI studies. Neuroimage 110, 11-21.
  7. Holtbernd, F., Deppe, M., Bachmann, R., Mohammadi, S., Ringelstein, E.B., Reilmann, R., 2015. Deficits in tongue motor control are linked to microstructural brain damage in multiple sclerosis: a pilot study. BMC Neurol. 15, 190.
  8. Klotz, L., Grutzke, B., Eveslage, M., Deppe, M., Gross, C.C., Kirstein, L., Posevitz-Fejfar, A., Schneider-Hohendorf, T., Schwab, N., Meuth, S.G., Wiendl, H., 2015. Assessment of immune functions and MRI disease activity in relapsing-remitting multiple sclerosis patients switching from natalizumab to fingolimod (ToFingo-Successor). BMC Neurol. 15, 96.
  9. Kramer, J., Deppe, M., Gobel, K., Tabelow, K., Wiendl, H., Meuth, S.G., 2015. Recovery of thalamic microstructural damage after Shiga toxin 2-associated hemolytic-uremic syndrome. J Neurol.Sci. 356, 175-183.
  10. Kramer, J., Meuth, S.G., Tenberge, J.G., Schiffler, P., Wiendl, H., Deppe, M., 2015. Early and Degressive Putamen Atrophy in Multiple Sclerosis. Int.J Mol.Sci. 16, 23195-23209.
  11. Deppe, M., Marinell, J., Kramer, J., Duning, T., Ruck, T., Simon, O.J., Zipp, F., Wiendl, H., Meuth, S.G., 2014. Increased cortical curvature reflects white matter atrophy in individual patients with early multiple sclerosis. Neuroimage Clin. 6, 475-487.
  12. Deppe, M., Muller, D., Kugel, H., Ruck, T., Wiendl, H., Meuth, S.G., 2013. DTI detects water diffusion abnormalities in the thalamus that correlate with an extremity pain episode in a patient with multiple sclerosis. Neuroimage Clin. 2, 258-262.
  13. Reilmann, R., Holtbernd, F., Bachmann, R., Mohammadi, S., Ringelstein, E.B., Deppe, M., 2013. Grasping multiple sclerosis: do quantitative motor assessments provide a link between structure and function? J.Neurol. 260, 407-414.
  14. Kleffner, I., Wersching, H., Schwindt, W., Kuhlmann, T., Keyvani, K., Deppe, M., Husstedt, I., 2011. Triad of visual, auditory and corticospinal tract lesions: a new syndrome in a patient with HIV infection. AIDS 25, 659-663.
  15. Kleffner, I., Deppe, M., Mohammadi, S., Schwindt, W., Sommer, J., Young, P., Ringelstein, E.B., 2010. Neuroimaging in Susac’s syndrome: focus on DTI. J.Neurol.Sci. 299, 92-96.
  16. Kleffner, I., Deppe, M., Mohammadi, S., Schiffbauer, H., Stupp, N., Lohmann, H., Young, P., Ringelstein, E.B., 2008. Diffusion tensor imaging demonstrates fiber impairment in Susac syndrome. Neurology 70, 1867-1869.